hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model
- Journal：International Journal of COPD
- Disease Model：Hydrogen inhalatio
- Corresponding Author：Xiaoyu liu, Cuiqing Ma, Xiaoyu Wang, Wenjing Wang, Zhu Li, Xiansheng Wang, Pengyu Wang, Wuzhuang sun, Baojian Xue
- Corresponding Unit：Hebei Medical College Dai-ichi Clinic
- Experimental Subject：Rats
- Way of Hydrogen Administration：Hydrogen inhalation
- Dosage：21% O2 + 2% H2 + 77% N2, 21% O2 +22% H2, 21% O2 +41.6% H2
- Duration：1h each time, and more than 4 hours another 1h, for a total of 4 months
These results suggest that hydrogen inhalation slows the development of COPD-like lung disease in a cigarette smoke-induced rat model. Higher concentrations of hydrogen may represent a more effective way for the rat model.
Molecular hydrogen is the smallest molecule known in nature, and it was regarded by the scientific community as the inert gas without biological effects. In 2007, Nature Medicine published a paper confirming that hydrogen inhalation can protect cerebral ischemia-reperfusion injury. As of now, nearly 1200 relevant papers have been published internationally confirming the biological effects of hydrogen, and involving 63 kinds of important human diseases.