Molecular hydrogen increases resilience to stress in mice
- Journal：Scientific Reports
- Disease Model：Depression, anxiety
- Corresponding Author：Qiang Gao, Han Song, Xiao-ting Wang Ying Liang, Yan-jie Xi, Yuan Gao, Qing-jun Guo, Tyler LeBaron, Yi-xianLuo, Shuang-cheng Li, XiYin, Hai-shui Shi, Yu-xia Ma
- Corresponding Unit：Scintific Reports
- Experimental Subject：Mice
- Way of Hydrogen Administration：Hydrogen inhalation
- Dosage：67% H2- 33%O2 mixture inhalation
Inhalation of hydrogen gas in adolescence significantly increased the resilience to acute stress in early adulthood, which illustrates the long-lasting effects of hydrogen on stress resilience in mice. This was likely mediated by inhibiting the hypothalamic-pituitary-adrenal axis and inflammatory responses to stress. These results warrant further exploration for developing molecular hydrogen as a novel strategy to prevent the occurrence of stress-related disorders.
Molecular hydrogen is the smallest molecule known in nature, and it was regarded by the scientific community as the inert gas without biological effects. In 2007, Nature Medicine published a paper confirming that hydrogen inhalation can protect cerebral ischemia-reperfusion injury. As of now, nearly 1200 relevant papers have been published internationally confirming the biological effects of hydrogen, and involving 63 kinds of important human diseases.