H2 inhibition of lung cancer through the influence of SMC3
- Journal：Biomedicine & Pharmacotherapy
- Disease Model：Lung cancer cell line
- Corresponding Author：Dongchang Wang, Lifei Wang, Gang Chen, et al.
- Corresponding Unit：No
- Experimental Subject：mice
- Way of Hydrogen Administration：67% H2 / 33% O2 Mixture
- Dosage：67% H2 / 33% O2 Mixture
- Duration：2h/d for 1 month
H2 can inhibit the growth, migration and invasion of cancer cells, and catalyze the apoptosis of cells. H2 induced A549 and H1975 remain in the g2/m phase of the cell cycle; In addition, H2 lowered NIBPL, SMC3, SMC5 and SMC6 expression ... All data showed that H2 can inhibit the progression of lung cancer and regulate SMC3, which provides a new method for the treatment of lung cancer.
Molecular hydrogen is the smallest molecule known in nature, and it was regarded by the scientific community as the inert gas without biological effects. In 2007, Nature Medicine published a paper confirming that hydrogen inhalation can protect cerebral ischemia-reperfusion injury. As of now, nearly 1200 relevant papers have been published internationally confirming the biological effects of hydrogen, and involving 63 kinds of important human diseases.