CH EN
Ascleway Papers
Home / Ascleway Papers / Paper Details

Effect of hydrogen-rich saline on mitochondrial permeability transition pore after focal cerebral ischemia reperfusion injury in rats

  • Time:2014年
  • Journal:江苏 医 药
  • Disease Model:Cerebral ischemia and reperfusion
  • Corresponding Author:崔苏扬(Suyang Cui)
  • Corresponding Unit:The Affiliated Hospital of Nanjing University of Chinese Medicine
  • Experimental Subject:Rats
  • Way of Hydrogen Administration:Hydrogen rich saline, intraperitoneal injection
  • Dosage:5 ml/kg
  • Duration:Single Test
Main Result

Compared with sham-operation group,  nerve function deficit score of all groups rise 48 hours after reperfusion, mPTP activity increases, mitochondrial transmembrane potential  is lowered and TUNEL positive cells increase. Compared model group, nerve function deficit score of hydrogen-rich group and hydrogen-rich water/atractyloside group declines, mPTP activity decreases, mitochondrial transmembrane potential  rises and TUNEL positive cells decrease. Compared with hydrogen-rich group, nerve function deficit score of hydrogen-rich water/atractyloside group rises, mPTP activity increases, mitochondrial transmembrane potential  is lowered and TUNEL positive cells increase.

Classification of Disease:Spinal cord and nerve system disease