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Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats

  • Time:2014年
  • Journal:Molecular and Cellular Biochemistry
  • Disease Model:Hypertension
  • Corresponding Author:Xiaohui Miao
  • Corresponding Unit:Changzheng Hospital, Second Military Medical University
  • Experimental Subject:Rats
  • Way of Hydrogen Administration:Hydrogen rich water, oral
  • Dosage:1.3 + 0.2 mg/L
  • Duration:In March
Main Result

Hydrogen-rich water has no effect on blood pressure of hypertensive rats but can lessen kidney injury. Hydrogen-rich water can reduce generation of active hydrogen, up-regulate SOD, glutathione peroxidase, glutathione -S- epoxide transferase and catalase activity, and suppress NADPH oxidase activity. Hydrogen-rich water can suppress expression of proinflammatory cytokine including TNF-α, IL-6, IL-1β and macrophage chemotactic factor 1. Hydrogen-rich water can also protect mitochondria function including formation of adenosine triphosphate and membrane integrity.